Advancement II — Night Repair Peptide Biotechnology
- Advancement II adds a novel peptide complex to the OUMERE system for nightly repair: structural support, elasticity, and visible smoothness.
- Designed to work with daytime Advancement, it completes a day–night peptide cycle that protects by day and renews by night.
- Formulated and manufactured in-house at OUMERE Laboratories—no outsourcing, no private label.
- Integrates seamlessly with No.9, UV-R, Serum Bioluminelle, and Oil Dissolution Theory.
Why I created Advancement II
The OUMERE routine is engineered to restore equilibrium so skin can perform its own biology: defend by day; repair by night. After two years of development, the Advancement II concentrate proved to be more than “more peptides.” In testing and personal use, I observed a notable increase in firmness, faster resolution of blemishes, and visible reduction in UV-induced uneven tone—consistent with targeted peptide signaling layered into the night phase.
How Advancement II fits the OUMERE routine
- Morning — Advancement (day): daily peptide support for firmness, elasticity, and hydrated resilience under daytime stressors.
- Evening — Advancement II (night): concentrated repair signaling during the natural nightly regeneration window.
Together they form a complete Advancement system: support by day, renewal by night, within the broader OUMERE method (controlled turnover, anti-inflammatory protection, lipid biophysics, and non-stripping cleansing).
Scientific mechanism (what the biology expects at night)
At night, skin prioritizes repair: DNA damage response, extracellular matrix maintenance, and barrier lipid synthesis. Advancement II targets this window with a peptide complex designed for:
- Signal transduction that encourages collagen-supportive pathways without inflammatory cost.
- Matrix organization to improve elasticity and smoothness (supporting collagen/elastin environment rather than over-stripping).
- Inflammation modulation to reduce the collateral damage that accelerates aging.
Peptide complex breakdown
- Tetrapeptide-21 & Tetrapeptide-30 — next-gen signal peptides associated with improved density/elasticity and more uniform tone.
- Acetyl Tetrapeptide-40 — targeted inflammation modulation to support an even, calm complexion.
- Hydrolyzed Ganoderma lucidum Extract — supports antioxidant defense and regenerative capacity; synergizes with peptide signaling.
- Acetyl Octapeptide-3 — helps relax expression lines for a smoother surface appearance.
Formulation note: signal intensity is adjusted to work with the OUMERE system’s controlled turnover and lipid restoration—no harsh acids or retinoid dependency required.
Day vs Night application (complete routine)
Morning
- No.9 Exfoliant (controlled PHA turnover; dilute if sensitized)
- Advancement (day peptide serum)
- UV-R (anti-inflammatory cellular protection)
- Serum Bioluminelle (lipid biophysics and structural comfort)
Evening
- Oil Dissolution Theory (non-stripping cleanse)
- Eye Serum
- Advancement II (night repair peptides)
- UV-R Concentrate
- Serum Bioluminelle Concentrate
The concentrates intensify the night phase with rare plant compounds and higher actives, compounding the peptide effect of Advancement II.
Observed results
Across a year of personal use and prototype feedback, common observations included: improved firmness/resilience, faster post-blemish recovery, and visible refinement in texture and tone. Effects were most pronounced when Advancement II was used consistently within the full OUMERE routine (No.9 → UV-R → Bioluminelle; ODT at night).
A true luxury skincare experience
Every bottle of Advancement II is laboratory-crafted in the OUMERE private lab. I formulate, pour, and box each unit—no private label shortcuts. This is scientific luxury: materials, methods, and control at every step.
No.9 — Controlled Exfoliation (PHA)
Smooths texture with minimal irritation; supports orderly desquamation.
UV-R — Anti-inflammatory Cellular Repair
Calms reactivity; protects collagen during daily stress.
Serum Bioluminelle — Lipid Biophysics
Locks in hydration and structural comfort with elegant finish.
Oil Dissolution Theory — Non-stripping Cleanse
Maintains microbiome and barrier lipids; no alkaline stress.
Further Reading & Research
Selected references
- Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Dermatology Reports, 9(1), 21–27. doi:10.4081/dr.2017.6984
- Lee, S. H., et al. (2019). Anti-inflammatory effects of acetylated tetrapeptides on UV-induced skin aging. Journal of Cosmetic Dermatology, 18(2), 484–490. doi:10.1111/jocd.12756
- You, Y. H., et al. (2017). Antioxidant and anti-aging effects of Ganoderma lucidum extracts on human skin. International Journal of Cosmetic Science, 39(1), 29–39. doi:10.1111/ics.12351
- Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with anti-wrinkle activity. International Journal of Cosmetic Science, 24(5), 303–310. doi:10.1046/j.1467-2494.2002.00153.x
- Rittié, L., & Fisher, G. J. (2002). Natural and sun-induced aging of human skin. Cold Spring Harbor Perspectives in Medicine, 5(1), a015370. doi:10.1101/cshperspect.a015370
Bottom line: Advancement II completes the OUMERE routine’s peptide architecture—support by day, renewal by night—delivering visible results through biologically coherent design.
Editor’s Lab Note
A note from the OUMERE Laboratory
Night repair is when skin prioritizes matrix maintenance and barrier lipid synthesis. Advancement II aligns with this window using targeted peptide signal transduction (Tetrapeptide-21/30; Ac-Tetrapeptide-40) and supportive actives (Ganoderma extract) to improve perceived density and smoothness without inflammatory debt. It’s a controlled alternative to irritation-based “anti-aging.” Continue reading in Lab Notes.